Tenif 50 mg/20 mg Capsules
atenolol 50 mg, nifedipine 20 mg
Read all of this leaflet carefully before you start taking this medicine.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
- If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
In this leaflet:
- 1. What Tenif is and what it is used for
- 2. Before you take Tenif
- 3. How to take Tenif
- 4. Possible side effects
- 5. How to store Tenif
- 6. Further information
What Tenif is and what it is used for
The name of your medicine is Tenif. It contains atenolol and nifedipine. Each of these works in a different way.
- Atenolol belongs to a group of medicines called beta-blockers. It works by making your heart beat more slowly and with less force. This helps to prevent chest pain.
- Nifedipine belongs to a group of medicines called dihydropyridines.
Dihydropyridines are a type of calcium channel blocker. They work by making your blood vessels widen. This helps to prevent chest pain and lowers your blood pressure.
Tenif is used to treat high blood pressure (hypertension) or to prevent chest pain (angina).
Before you take Tenif
Do not take Tenif if:
- You are having an angina attack (sudden chest pain). Tenif cannot treat an angina attack, but it can help you get fewer attacks if you take it regularly.
- You are allergic (hypersensitive) to Tenif, Tenormin, atenolol, nifedipine, or anything else in this medicine (see Section 6: Further information).
- You are allergic (hypersensitive) to other dihydropyridines such as amlodipine or felodipine.
- You have any of the following heart problems:
- heart failure which is not under control (this usually makes you breathless and causes your ankles or legs to swell)
- second- or third-degree heart block (a condition which may be treated with a pacemaker)
- a very slow or very uneven heart beat, very low blood pressure or very poor circulation
- a heart attack within the last month
- a heart condition called sick sinus syndrome, or unstable angina, or aortic stenosis
- a condition where the heart is unable to supply enough blood to the body (cardiogenic shock).
- You have problems with your kidneys.
- You have a tumour called phaeochromocytoma that is not being treated. This is usually near your kidney and can cause high blood pressure.
- Your doctor has told you that you have higher than normal levels of acid in your blood (metabolic acidosis).
- You have not been eating much recently.
- You are taking a medicine called rifampicin.
- You are taking a medicine that is a certain type of calcium channel blocker such as verapamil or diltiazem.
- You are a woman at an age where you could get pregnant, or you are pregnant or breast-feeding (see the section on "Pregnancy and breast-feeding" below).
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Tenif.
Take special care with Tenif
Before you take Tenif, tell your doctor if:
- You have asthma, wheezing or similar breathing problems, or you get allergic reactions, such as to insect stings. If you have ever had asthma or wheezing, do not take this medicine without first checking with your doctor.
- You have a type of chest pain (angina) called Prinzmetal's angina.
- You have poor blood circulation or controlled heart failure.
- You have first-degree heart block (a condition which may be treated by a pacemaker).
- You have liver problems. Your doctor may need to do tests during your treatment with Tenif to check how well your liver is working.
- You have diabetes. Your medicine may change how you respond to having low blood sugar. You may feel your heart beating faster.
- You have thyrotoxicosis (a condition caused by an overactive thyroid gland). Your medicine may hide the symptoms of thyrotoxicosis.
- You are a man whose female partner is having IVF (in-vitro fertilisation treatment). This is because Tenif can affect your sperm.
If you give a urine sample, it is important to tell your doctor that you are taking Tenif. This is because Tenif may interfere with the urine test results.
Taking other medicines
Please tell your doctor or pharmacist if you are taking, or have recently taken, any other medicines. This includes herbal medicines and medicines that you buy without a prescription. Tenif can affect the way that some other medicines work and some medicines can have an effect on Tenif.
You must not take Tenif if you are taking any of the following medicines:
- Rifampicin (for tuberculosis).
- Other dihydropyridines such as amlodipine or felodipine (for high blood pressure or heart problems).
- Certain calcium channel blockers such as verapamil or diltiazem (for high blood pressure or chest pain).
Tell your doctor or pharmacist if you are taking any of the following medicines:
- Clonidine (for high blood pressure or migraine). If you are taking clonidine and Tenif together, do not stop taking clonidine unless your doctor tells you to do so. If you have to stop taking clonidine, your doctor will tell you how to do it.
- Disopyramide, quinidine or amiodarone (for an uneven heart beat).
- Digoxin or digitoxin (for heart problems).
- Adrenaline, also known as epinephrine (a medicine that stimulates the heart).
- Ibuprofen or indometacin (for pain and inflammation).
- Insulin or medicines that you take by mouth for diabetes.
- Medicines to treat nose and sinus congestion or other cold remedies (including those you buy in the pharmacy).
- Cimetidine (for stomach problems).
If you go into hospital to have an operation, tell the anaesthetist or doctor that you are taking Tenif. This is because you can get low blood pressure (hypotension) if you are given certain anaesthetics while you are taking Tenif.
Pregnancy and breast-feeding
- Do not take Tenif if you are pregnant or at an age where you could get pregnant. This is because Tenif can harm your unborn baby.
- Do not take Tenif if you are breast-feeding.
Driving and using machines
- Your medicine is not likely to affect driving or using tools or machines. However, it is best to wait to see how your medicine affects you before trying these activities.
- If you feel dizzy or tired when taking this medicine, ask your doctor for advice.
Taking Tenif with food and drink
Do not drink grapefruit juice within 2 hours of taking Tenif. This is because your blood pressure may be reduced too much, which may make you feel dizzy.
How to take Tenif
Always use your medicine exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
- Swallow the capsules with a drink of water.
- Your doctor will tell you how many capsules to take each day and when to take them. Also read the label on the carton.
Adults with high blood pressure (hypertension)
The usual dose is one capsule each day.
Adults with chest pain (angina)
The usual dose is one capsule every 12 hours.
Older people (aged over 65 years)
High blood pressure (hypertension): The dose should not be more than one capsule each day.
Chest pain (angina): The dose should not be more than one capsule every 12 hours.
People with liver problems
The dose should not be more than one capsule each day.
Children
Your medicine must never be given to children.
If you take more Tenif than you should
If you have taken more of your medicine than prescribed by your doctor, tell your doctor or go to the nearest hospital casualty department straight away. Take the medicine packaging with you.
If you forget to take Tenif
If you forget to take a dose, take it as soon as you remember. If it is almost time to take the next dose, wait until then. Do not take a double dose.
If you stop taking Tenif
Do not stop taking your medicine without first talking to your doctor. In some cases, you may need to stop taking it gradually.
Tenif Side Effects
Like all medicines, Tenif can cause side effects, although not everybody gets them.
Important side effects to look out for:
If you get any of the following, see a doctor straight away:
- Raised lumps on your skin (weals) or swelling of your face, lips, mouth, tongue or throat. This means that you are having an allergic reaction.
- Pain in your chest when you start taking Tenif.
Other possible side effects:
Heart and circulation: swelling of the feet or ankles or other parts of the body; slower, faster, or uneven heart beat; pounding heart beat (palpitations); angina (pain in chest) made worse; feeling faint (especially when standing up); cold hands and feet; feeling numb with spasms in your fingers (Raynaud's disease); heart block (which can cause dizziness or fainting); pain in the muscles of the leg that occurs off and on, usually while walking or exercising; decreased blood pressure in patients on kidney dialysis.
Nervous system: feeling tired or confused; headache; feeling dizzy; mood changes; nightmares; changes in personality; hallucinations; difficulty in sleeping; tingling hands or feet.
Chest: feeling breathless or wheezy.
Blood: a reduced number of platelets in your blood which may make you bleed more easily; a severe reduction in the number of white blood cells which makes infections more likely.
Digestive system: dry mouth; enlarged gums; diarrhoea; feeling sick; liver problems and jaundice (yellowing of your skin or the whites of your eyes).
Skin and hair: flushing of your skin; bruising more easily or purple marks on your skin; skin rashes; lumpy rash (hives); flaking or peeling skin; being sensitive to sunlight; hair loss; a condition called erythromelalgia, the signs include redness, swelling, and burning pain in the hands and feet.
Sexual: being unable to get an erection (impotence); enlarged breasts in older men.
Eyes: problems with your sight; dry eyes.
Urinary: passing water (urine) more often.
Muscles: muscle pain; shaking (tremor); burning pain in your legs.
Conditions that may get worse
If you have any of the following conditions, they may get worse when you start to take your medicine:
- Psoriasis (a skin condition).
- Being short of breath or having swollen ankles (if you have heart failure).
- Asthma or breathing problems.
- Poor blood circulation.
Do not be concerned by this list of possible side effects. You may not get any of them. If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
How to store Tenif
- Keep out of the reach and sight of children.
- Do not store this medicine above 30°C.
- Store in the original package. Keep the blister pack in the outer carton. This will protect your medicine from light and moisture.
- Do not use your medicine after the expiry date that is stated on the packaging.
The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Further information
What Tenif Capsules contain
- The active ingredients are 50 mg atenolol and 20 mg nifedipine per capsule.
- The other ingredients are gelatin, iron oxide (E172), lactose, macrogol, magnesium carbonate, magnesium stearate, maize starch, methylhydroxypropylcellulose, microcrystalline cellulose, polysorbate, sodium laurilsulfate and titanium dioxide (E171).
What Tenif Capsules look like and contents of the pack
Tenif Capsules are a reddish-brown colour. They come in a blister pack containing 28 capsules.
Marketing Authorisation Holder and Manufacturer
The Marketing Authorisation for Tenif Capsules is held by
Tenif Capsules are manufactured by
To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge:
0800 198 5000 (UK only)
Please be ready to give the following information:
Product name Tenif Capsules
Reference number 17901/0047
This is a service provided by the Royal National Institute of Blind People.
Leaflet prepared: October 2009.
© AstraZeneca 2009
Tenif is a trade mark of the AstraZeneca group of companies.
CV 09 0089a
P026068
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